If you’d love to inhabit the Twitosphere but find it somewhat inaccessible, then you might want to try Accessible Twitter. Among other features, it provides keyboard accessible links, a larger default text size, and audio cues which let you know when you’re reaching your character limit.
The application is still at alpha stage with more features at the task list and wish list stage. There’s also an interview with its creator, Dennis Lembree, over on the Accessify blog, which will give you a good insight into how the design came about.
Whilst most Web 2.0 apps are initially inaccessible, once they become mainstream, there does seem to be a drive by independent developers to try make them accessible (providing they can hook into the relevant bits of the backend code). So is this almost collaborative approach to producing accessible, usable apps the way forward rather than trying to do everything in-house?